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KMID : 0385919940050010059
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Journal of the Korean Society of Emergency Medicine
1994 Volume.5 No. 1 p.59 ~ p.65
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The Effect of High Dose Epinephrine During Cpr of Cardiac Arrest
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Abstract
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Study objectives;
@EN To compare the return of spontaneous circulation(RSC) rates in cardiac arrest treated with standard doses of epinephrine (SDE) or high dose epinephrine (HDE).
@ES Design;
@EN prospective.
@ES Setting;
@EN The WonKwang university hospital emergency department during July, 1991 through December, 1993.
@ES Participants;
@EN 56 adult victims of nontraumatic cardiac arrest.
Interventions; At the discretion of the treating physician, patients received epinephrine in bolus doses ranging from 1 to 15mg. HDE was defined as a dose of at least 0.15mg/kg; smaller doses were defined as SDE. Patient was grouped as +RSC if
they
developed a sustained spontaneous palpable pulse or blood pressure and as -RSC if they did not develop a pulse or blood pressure.
@ES Measurements;
@EN Patient were grouped as +RSC and -RSC. Patients were also grouped by their presenting rhythm. Potentially perfusing rhythm was electromechanical dissociation or ventricular tachycardia. Nonperfusing rhythm was asystole or ventricular
fibrillation.
Rate were analyzed using the Chi-square test and the two tailed unpaired t-test (p=0.185). The effects were greatest in patients with nonperfusing rhythms(p=0.119). One patient survived to hospital discharge.
@ES Conclusion;
@EN High-dose epinephrine improves initial resuscitation rates in cardiac arrest. Its greatest effect is in patients with a nonperfusing rhythm.
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KEYWORD
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